Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?
نویسندگان
چکیده
منابع مشابه
Calcium sequestration by the sarcoplasmic reticulum in heart failure.
Myocardial contraction and relaxation are dependent w 2qx upon the rise and fall of cytosolic Ca in cardiac myocytes. The release and sequestration of Ca by the sarcoplasmic reticulum are the principal mechanisms through which this occurs. During relaxation, Ca is actively transported from the cytosol into the sarcoplasmic reticulum; during contraction, this sequestered Ca is passively released...
متن کاملSarcoplasmic reticulum in heart failure: central player or bystander?
Ronald M. Phillips , Prakash Narayan , Ana M. Gomez , Keith Dilly , Larry R. Jones , ́ W. Jonathan Lederer , Ruth A. Altschuld a,) a Department of Medical Biochemistry, Ohio State UniÕersity Medical Center, 333 Hamilton Hall, 1645 Neil AÕenue, Columbus, OH 43210-1218, USA b Departments of Molecular Biology and Biophysics and Physiology, UniÕersity of Maryland School of Medicine, Baltimore, MD 21...
متن کاملSarcoplasmic Reticulum Ca Homeostasis and Heart Failure
Heart function vitally relies on precisely controlled intracellular Ca homeostasis during each cardiac cycle. Abnormalities in Ca regulation cause contractile dysfunction and arrhythmias under different pathological conditions including heart failure (HF). Playing a particularly important role in heart contraction is the sarcoplasmic reticulum (SR). In adult ventricular myocytes, the SR forms a...
متن کاملChanges in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure
ii Acknowledgements iv List of Tables viii List of Figures xi Chapter 1: Introduction
متن کاملIlluminating sarcoplasmic reticulum calcium.
The bulk of the Ca 2 that activates contraction in the heart comes from the sarcoplasmic reticulum (SR). Calcium is released by the process of Ca -induced Ca release (CICR) in which the entry of a small amount of Ca across the cell membrane triggers the release of much more from the SR. This mechanism depends on the fact that Ca entry from the extracellular fluid (via the L-type Ca current) inc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Reviews
سال: 2020
ISSN: 1867-2450,1867-2469
DOI: 10.1007/s12551-020-00736-y